Do you drive? It's not precisely work at home, but some people make very good money delivering bundles of papers to the people who go house-to-house to deliver them, and that job takes place late at night when you don't have to interact with almost anyone.
There's also domestic work. If you can iron, mend, and do laundry, you can do that for people...a sort of "drop off your laundry in the morning and it'll be washed, ironed, and folded for you after your workday" thing. Depending on your home, you may be able to pet-sit in your house while people are on vacation. If you've an eye for detail, you can proofread, which can bring in a little money, and if you're creative, you can do graphics, writing, ads, or websites for small businesses. It won't make you rich, but you can bring in a subsistence wage that way.
In my experience, you will find more work-at-home possibilities by examining what your talents and abilities are and comparing it with what other people can't do or don't have time to do or don't like to do than you will by searching online or calling those "work at home" numbers listed in the newspaper. Find a niche. Some people really hate typing, but find they must have reports/lettters typed and will pay you to do it. Some people will pay to learn basic computer skills (so long as you charge less than local businesses for the same service).
If avoiding extensive social interaction is part of the reason you want a work at home job, consider part-time freight work or overnight stocking for retail businesses, inventory (which is typically completed late at night or in the early morning, can pay upwards of $15 USD an hour, and basically just means you count products and write down the numbers), or seasonal support work. The most enjoyable job I ever had was working blessedly solitary inventory on new textbooks for an elementary school before the school year started, and it paid okay, too. Churches may also have part-time office work they'll let you do (such as filing, copying, data-entry, and typing up a bulletin every week), and they may be more accomodating than traditional employers.
And don't discount your relatives. Maybe an aunt or uncle works at an office that had an employee quit, and they need help managing the paperwork. Maybe someone knows someone who needs envelopes stuffed. Family can often ferret out possibilities that strangers wouldn't bother doing for you, so that's worth a try.
Good luck.
