03-05-2006, 09:02 AM
Lead-removal drug linked to 2 deaths
By Mike Stobbe
Associated Press
6th March 2006
ATLANTA -- A drug that is sometimes used to treat lead poisoning -- and is also believed by some parents to be effective against autism -- caused the deaths of two children last year, the government said this past week.
One youngster was autistic; the other had lead poisoning.
The deaths mark the first documented link between a chelation drug and cardiac arrest in children, according to the Centers for Disease Control and Prevention. Both children were treated with a product called Endrate.
Mary Jean Brown, chief of the CDC's Lead Poisoning Prevention Branch, said hospital pharmacies should consider whether stocking Endrate is necessary, given its risks and the availability of other treatments.
The maker of Endrate, Hospira Inc., had no immediate comment.
Chelating agents are chemical compounds that latch on to metals in the body and carry them out through urine or feces. Chelation is commonly used for lead poisoning.
Some doctors have used chelation to treat autism, believing mercury or other heavy metals cause the condition's symptoms. However, medical evidence does not support that belief, and the drug is not approved for that use, CDC officials said.
Since at least 1978, federal health officials have warned against giving it to children with lead poisoning.
By Mike Stobbe
Associated Press
6th March 2006
ATLANTA -- A drug that is sometimes used to treat lead poisoning -- and is also believed by some parents to be effective against autism -- caused the deaths of two children last year, the government said this past week.
One youngster was autistic; the other had lead poisoning.
The deaths mark the first documented link between a chelation drug and cardiac arrest in children, according to the Centers for Disease Control and Prevention. Both children were treated with a product called Endrate.
Mary Jean Brown, chief of the CDC's Lead Poisoning Prevention Branch, said hospital pharmacies should consider whether stocking Endrate is necessary, given its risks and the availability of other treatments.
The maker of Endrate, Hospira Inc., had no immediate comment.
Chelating agents are chemical compounds that latch on to metals in the body and carry them out through urine or feces. Chelation is commonly used for lead poisoning.
Some doctors have used chelation to treat autism, believing mercury or other heavy metals cause the condition's symptoms. However, medical evidence does not support that belief, and the drug is not approved for that use, CDC officials said.
Since at least 1978, federal health officials have warned against giving it to children with lead poisoning.